4/3/2023 0 Comments Covid spike protein![]() NCTM’s spike proteins will also be useful once a COVID-19 vaccination is available. Similarly, NCTM researchers are making versions of COVID-19 spike proteins that can be used to measure antibody responses to the SARS-CoV-2 virus spike proteins in order to aid in the recombinant development of these antibodies in the future. Doctors and scientists identified antibodies in his blood that could recognize the Ebola virus and prevent it from multiplying further in patients. Kent Brantly, who survived Ebola, then donated his plasma to help others recover as well. NCTM’s strategy is derived from what happened with Dr. Zivko Nikolov, professor in the Department of Biological and Agricultural Engineering at Texas A&M University and director of NCTM. “There are hundreds of virus-fighting antibodies in plasma, and using recombinant spike proteins is the fastest way to detect the correct ones we need to fight COVID-19,” said Dr. NCTM is producing spike proteins to identify antibodies that can attach to the SARS-CoV-2 spike protein receptor-binding domain and prevent the virus from binding to key sites, thus obstructing the virus from entering and infecting human cells. Preventing this binding is easier said than done, but the Texas A&M Engineering Experiment Station’s (TEES) National Center for Therapeutics Manufacturing (NCTM) has received funding from the National Institute for Innovation in Manufacturing Biopharmaceuticals (NIIMBL) to help find a way to do just that. ![]() Researchers could theoretically eliminate the threat of the coronavirus if they can discover how to prevent this virus from binding to cells in the first place. ![]() SARS-CoV-2 (also known as severe acute respiratory syndrome coronavirus 2) is the virus that infects cells and causes the coronavirus disease in humans. "In light of all the different variants that are emerging and the difficulty in preventing infection from each one individually, it might be beneficial to focus on these triggers of pathogenesis in addition to blocking infection altogether," said Scott Biering, a UC Berkeley postdoctoral scholar and lead author of the study.As the coronavirus pandemic continues to surge worldwide, there is an urgent need for anything that can bring us closer to a vaccine or treatment that will protect people from future infections. ![]() The study, published Friday in the journal "Nature Communications," found that the spike protein on COVID virus particles can damage the walls of blood vessels throughout the body, causing a condition known as vascular leak.Īs a result, plasma and other fluids carried in blood vessels can lead to the lung and heart damage that often occurs in severe COVID cases.īlocking the protein's damage to blood vessels could thus help prevent some of the virus' most serious symptoms and outcomes, according to the researchers. BERKELEY (CBS SF/BCN) – COVID-19's spike protein may contribute to blood vessels secreting fluids into a person's body, which can lead to severe health outcomes like respiratory failure, according to a study from researchers at the University of California, Berkeley. ![]()
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